Clinical Trials at Retina Northwest
Retina Northwest is committed to fostering cutting edge treatments for retinal diseases through our participation in clinical trials. Brief descriptions of our active clinical trials are listed below. If you are a physician and have questions about any of our trials, or if you would like to refer a patient to our care, please contact our Clinical Research department at 503-274-2121.
Age-Related Macular Degeneration (AMD)
Atrophic (“Dry”)
APL2-GA-305 (Dry AMD)
Principal Investigator: Colin Ma, MD
Study Coordinator: Jessica Cardin
Active, Enrollment Closed
Gale: A phase 3, open-label, multicenter, extension study to evaluate the long-term safety and efficacy of pegcetacoplan in subjects with geographic atrophy secondary to age-related macular degeneration.
ISEE2008 (Dry AMD)
Principal Investigator: Michael Lee, MD
Study Coordinator: Jessica Cardin
Active, Enrollment Closed
ISEE2008: A phase 3 multicenter, randomized, double-masked, shamcontrolled clinical trial to assess the safety and efficacy of intravitreal administration of Zimura™ (complement C5 inhibitor) in patients with geographic atrophy secondary to age-related macular degeneration.
Exudative (“Wet”)
Aerie (DME and Wet AMD)
Principal Investigator: Paul Tlucek MD
Study Coordinator: Brian Puckett
Active, Enrollment Pending
Phase 1/2a Study of the Safety of AR-13503 Sustained Release Intravitreal Implant in Subjects with Neovascular Age-Related Macular Degeneration (nAMD) and Subjects with Diabetic Macular Edema (DME).
GR42691 (Wet AMD)
Principal Investigator: Apurva Patel, MD
Study Coordinator: Brian Heimdahl
Active, Enrollment Closed
Avonelle-X: A multicenter long-term extension study designed to evaluate the long-term safety and tolerability of faricimab in patients with neovascular age-related macular degeneration.
Portal (Wet AMD)
Principal Investigator: Paul Tlucek, MD
Study Coordinator: Brian Puckett and Ashley Adamo
Active, Enrollment Closed
A multicenter, open-label extension study to evaluate the long-term safety and tolerability of the port delivery system with ranibizumab in patients with Neovascular Age-Related Macular Degeneration.
20968 (Wet AMD)
Principal Investigator: Michael Lee, MD
Study Coordinator: Jessica Cardin
Active, Enrollment Closed
Pulsar: Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration.
Diabetic Eye Diseases
Diabetic Retinopathy
Principal Investigator: Paul Tlucek MD
Study Coordinator: Brian Puckett
Active, Currently Enrolling
Phase 1/2a Study of the Safety of AR-13503 Sustained Release Intravitreal Implant in Subjects with Neovascular Age-Related Macular Degeneration (nAMD) and Subjects with Diabetic Macular Edema (DME).
Principal Investigator: Apurva Patel MD
Study Coordinator: Brian Puckett and Ashley Adamo
Active, Currently Enrolling
Randomized Trial of Intravitreous Aflibercept vs. Intravitreous Bevacizumab plus Aflibercept for Treatment for Central-Involved Diabetic Macular Edema.
Principal Investigator: Paul Tlucek MD
Study Coordinator: Ashley Adamo
Active, Currently Enrolling
A Pilot Study evaluating Photobiomodulation Therapy for Diabetic Macular Edema (Protocol AE).
Principal Investigator: Mark Peters, MD
Study Coordinator: Brian Puckett and Ashley Adamo
Active, Enrollment Closed
A Comparative Effectiveness Study of Intravitrela Aflibercept, Bevacizumab and Ranibizumab for Diabetic Macular Edema Extension Study
KS301P104 (DME)
Principal Investigator: Apurva Patel, MD
Study Coordinator: Brian Heimdahl
Active, Enrollment Closed
Gleam: A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Two-arm, Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared with Intravitreal Aflibercept in Participants with Visual Impairment Secondary to Treatment-naïve Diabetic Macular Edema (DME).
Vein Occlusions
KS301P103 (RVO)
Principal Investigator: Apurva Patel, MD
Study Coordinator: Brian Heimdahl
Active, Enrollment Closed
Beacon: A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Two-arm, Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared with Intravitreal Aflibercept in Participants with Visual Impairment Due to Treatment-naïve Macular Edema Secondary to Retinal Vein Occlusion (RVO).
GR41986 (CVO)
Principal Investigator: Apurva Patel, MD
Study Coordinator: Brian Heimdahl
Active, Enrollment Closed
Comino: A phase III, multicenter, randomized, double-masked, active comparator controlled study to evaluate the efficacy and safety of Faricimab in patients with macular edema secondary to central retinal or hemiretinal vein occlusion.
Macular Telangiectasia
Principal Investigator: Michael Lee, MD
Study Coordinator: Brian Puckett
Registry Only
A natural history observation and registry study of Macular Telangiectasia Type 2: The MacTel Study
Neurotech Macular Telangiecasia Surgical Study Phase 3
Principal Investigator: Michael Lee, MD
Study Coordinator: Brian Puckett
Active, Currently Enrolling
A phase III multicenter randomized, sham controlled, study to determine the safety and efficacy of Renexus in Macular Telangiectasia Type 2.
